Drug Discovery

Piramal Discovery Services (PDS) site in Ahmedabad offers integrated, high-quality services supported by a dedicated project management team. Our integrated drug discovery approach combines chemistry, biology, ADME, route scouting, and scale-up capabilities under the same roof, enabling seamless progression from hit identification to lead candidate selection. In addition, with our partner offering DMPK and early-toxicology services (GLP or non-GLP), we provide a full-package solution, coordinated by experienced project managers, ensuring efficient workflows, robust data generation, and on-time decision-making to select the best preclinical candidates. Once the preclinical candidate selected and even before, we can connect you with our Piramal network of CDMO to anticipate the next steps and increase your chances of success from the drug development up to the commercialization of your product.

Synthetic Chemistry Services for Drug Discovery

The specialized team at Piramal Discovery Solutions (PDS) boasts broad experience in preparing high quality small molecule NCEs which makes usone of the most rusted synthetic chemistry services providers for mg to kg scale discovery chemistry. We are proficient in developing methodologies, including the synthesis of single-step, multi-step and small arrays, as well as designing focused libraries to support our customers across all stages of the research pipeline, from hit identification to lead nomination, with a focus on timelines and confidentiality at each step.

 Access to scientific literature and databases such as SciFinder and Reaxys enables the team to modify and develop novel synthetic routes. Compound delivery is accompanied with analytical data including high-field NMR, and mass and purity by LC-MS/HPLC/GC. Also, Supercritical Fluid Chromatography aids chiral separation and generates a higher throughput. Our teams collaborate closely with biology and DMPK to optimize potency, selectivity, and developability. Synthetic strategies are selected with attention to project goals and intellectual property requirements, enabling the progression of promising compounds toward preclinical development.

Piramal's in vitro biology services are designed to provide best-in-class support for preclinical drug discovery to gain insights into compound activity, mechanism of action and safety. Our offerings span the research pipeline from hit identification, hit-to-lead and lead optimization, incorporating single plex or multiplex assay development, biochemical and cell-based assays. Each assay is tailored to address customer's needs and validated rigorously using tool compounds with QC established (signal: noise ratio, Z'-prime uniformity and reproducibility).

Reliable in vitro ADME Services for Drug Discovery

Our in vitro facilities deliver comprehensive services including absorption, distribution, metabolism, and excretion (ADME) solutions. These services support faster and more informed decision-making in drug discovery programs or as standalone offerings and help to reduce the risk of costly late-stage failures.

Clients benefit from cost-efficient, standardized, and customized assays for assessing key ADME parameters, ensuring precise and reliable results tailored to their unique project requirements.

For more than 10 years, we have partnered with trusted service providers for in vivo pharmacology, DMPK and toxicology services for a full characterization of your compound. The facilities ensure the highest standards of animal welfare and holds AAALAC accreditation, and are also GLP-accredited. Our partners offer validated diseases models across multiple therapeutic areas, as well as a comprehensive portfolio of DMPK assays for a complete characterization of your compound. Lastly we also offer non-GLP and GLP toxicology studies to evaluate systemic and local toxicity following single or repeated doses.

In Vivo Pharmacology

• Oncology
• metabolic diseases
• Pain, inflammation
• Neurology
• Dermatology
• Woman Health
• Organ health
• others

Reliable in vitro ADME Services for Drug Discovery

Our in vitro facilities deliver comprehensive services including absorption, distribution, metabolism, and excretion (ADME) solutions. These services support faster and more informed decision-making in drug discovery programs or as standalone offerings and help to reduce the risk of costly late-stage failures. Clients benefit from cost-efficient, standardized, and customized assays for assessing key ADME parameters, ensuring precise and reliable results tailored to their unique project requirements. In addition, for more than 10 years, we have partnered with trusted service providers for in vivo pharmacology, DMPK and toxicology services for a full characterization of your compound. The facilities ensure the highest standards of animal welfare and holds AAALAC accreditation, and are also GLP-accredited. Our partners offer validated diseases models across multiple therapeutic areas, as well as a comprehensive portfolio of DMPK assays for a complete characterization of your compound. Lastly we also offer non-GLP and GLP toxicology studies to evaluate systemic and local toxicity following single or repeated doses

Our fully equipped kilo lab enables the rapid development of scalable and robust chemical processes using advanced methodologies with speed and quality. This capability is critical for ensuring quick supply during the early development phase and for evaluating the scalability of the original process. Our team can also work closely with the development expert for a seamless transition to GMP production batches