Your Partners in Unlocking New Possibilities. Meet Our Leadership at CPHI Frankfurt at Booth No. 5.0C84.
Book a Meeting
Your Partners in Unlocking New Possibilities. Meet Our Leadership at CPHI Frankfurt at Booth No. 5.0C84.
Book a Meeting
Piramal's Discovery Services (PDS) site in Ahmedabad, India, provide comprehensive drug discovery services, including synthetic chemistry, in vitro biology, in vitro ADME, in vivo pharmacology, DMPK, safety and toxicology services, route scouting, and non-GMP scale-up. We serve a diverse range of customers: large and mid-sized pharma companies, biotechs and start-ups, academic institutions as well as applied markets (cosmetics, food and beverage, seed, animal care) worldwide. Since commencing operations in early 2003, we have focused on delivering customer projects, growing into a team of over 300 scientists working in world-class chemistry and biology laboratories. PDS can provide forward integration with the company's drug substance and formulation sites in North America, UK & India, ensuring seamless support throughout the drug development lifecycle.
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The specialized team at Piramal Discovery Solutions (PDS) boasts broad experience in preparing high quality small molecule NCEs which makes usone of the most rusted synthetic chemistry services providers for mg to kg scale discovery chemistry. We are proficient in developing methodologies, including the synthesis of single-step, multi-step and small arrays, as well as designing focused libraries to support our customers across all stages of the research pipeline, from hit identification to lead nomination, with a focus on timelines and confidentiality at each step.
Access to scientific literature and databases such as SciFinder and Reaxys enables the team to modify and develop novel synthetic routes. Compound delivery is accompanied with analytical data including high-field NMR, and mass and purity by LC-MS/HPLC/GC. Also, Supercritical Fluid Chromatography aids chiral separation and generates a higher throughput. Our teams collaborate closely with biology and DMPK to optimize potency, selectivity, and developability. Synthetic strategies are selected with attention to project goals and intellectual property requirements, enabling the progression of promising compounds toward preclinical development.
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Piramal's in vitro biology services are designed to provide best-in-class support for preclinical drug discovery to gain insights into compound activity, mechanism of action and safety. Our offerings span the research pipeline from hit identification, hit-to-lead and lead optimization, incorporating singleplex or multiplex assay development, biochemical and cell-based assays. Each assay is tailored to address customer's needs and validated rigorously using tool compounds with QC established (signal:noise ratio, Z'-prime uniformity and reproducibility).
Reliable in vitro ADME Services for Drug Discovery
Our in vitro facilities deliver comprehensive services including absorption, distribution, metabolism, and excretion (ADME) solutions. These services support faster and more informed decision-making in drug discovery programs or as standalone offerings and help to reduce the risk of costly late-stage failures.
Clients benefit from cost-efficient, standardized, and customized assays for assessing key ADME parameters, ensuring precise and reliable results tailored to their unique project requirements.
Our fully equipped kilo lab enables the rapid development of scalable and robust chemical processes using advanced methodologies with speed and quality. This capability is critical for ensuring quick supply during the early development phase and for evaluating the scalability of the original process. Our team can also work closely with the development expert for a seamless transition to GMP production batches
The analytical team collaborates with the chemists and leads method development, preparative purification and characterization, allowing the chemists to focus on trouble-shooting which ensures better efficiencies and faster deliveries.
For more than 10 years, we have partnered with trusted service providers for in vivo pharmacology, DMPK and toxicology services for a full characterization of your compound. The facilities ensure the highest standards of animal welfare and holds AAALAC accreditation, and are also GLP-accredited. Our partners offer validated diseases models across multiple therapeutic areas, as well as a comprehensive portfolio of DMPK assays for a complete characterization of your compound. Lastly we also offer non-GLP and GLP toxicology studies to evaluate systemic and local toxicity following single or repeated doses
In Vivo Pharmacology
Piramal Pharma has over 60 years of expertise in small molecule API development and manufacturing. Our global facilities are equipped to meet your drug substance needs, with dedicated development resources worldwide. As a reliable supply chain partner globally, we support your drug substance development goals.
We offer comprehensive support for custom API development, covering Route Scouting, Pre-GMP Kilo Lab, Process Development, and Analytical Development, with expertise and flexibility.
We offer manufacturing services at lab, kilo, and pilot scales, catering to preclinical studies, all stages of clinical trials, and commercialization, providing quantities ranging from milligrams to kilograms.
Piramal’s Generic API division provides a diverse range of off-patent APIs tailored for global markets.
Piramal’s Riverview facility offers High Potency API (HPAPI) services. Our teams are experts in the cGMP production of highly potent compounds, from grams to kilograms. With over 50 years of experience in manufacturing, handling, and containment of highly potent compounds, we prioritize safety and quality in all our operations.
