Piramal’s Discovery Services (PDS) site in Ahmedabad, India, provides comprehensive discovery services including synthetic chemistry, in-vitro biology, in-vitro ADME, route scouting, and non-GMP scale-up to large/mid-size pharma, biotechs and academic institutions around the world. We commenced our operations in early 2003, focusing on aiding start-ups and biotech companies and have now grown to a team of over 300 scientists working in world-class chemistry laboratories. PDS can provide forward integration with the company’s drug substance and formulation sites in North America, UK and India.
The specialized team at Piramal Discovery Solutions (PDS) makes it one of the most reputed service providers for mg to kg scale discovery chemistry requirements and boasts of a broader experience in preparing high quality small molecule NCEs. PDS is proficient in developing methodologies, including the synthesis of single, multi-step, small arrays as well as designing of focused libraries for use in hit-to-lead and lead optimization projects.
Access to scientific literature and databases such as SciFinder and Reaxys enables the team to modify and develop novel synthetic routes. Compound delivery is accompanied with characterization data including high-field NMR, and mass and purity by LC-MS/HPLC/GC. Also, the Supercritical Fluid Chromatography aids chiral separation and generates a higher throughput.
Piramal’s in vitro Biology is designed to provide best in class support to our clients to enable their preclinical drug discovery, including assay development, hit identification, hit-to-lead and lead optimization, including HTS, multiplex assay development, primary/secondary functional assays, HCS, and selectivity. Our assay team can develop, and screen compounds, with miniaturization of assays achieved by using 96 and 384-well plates. Our assays are validated rigorously using tool compounds with QC established (signal: noise ratio; Z’-prime; uniformity; reproducibility).
In vitro facilities at Piramal Discovery Services, Ahmedabad provide absorption, distribution, metabolism, and excretion (ADME) services for faster and improved decision making points or standalone offering to support drug discovery programs. Cost-efficient, standardized and customized assays for ADME parameters are provided to the clients.
Our fully equipped kilo lab provides rapid development of scalable and robust chemical processes using advanced process methodologies which is critical for quick supply in the early development phase and to understand the scalability of the original process.
The analytical team collaborates with the chemists and leads method development, preparative purification and characterization, allowing the chemists to focus on trouble-shooting which ensures better efficiencies and faster deliveries.
Piramal Pharma has over 60 years of expertise in small molecule API development and manufacturing. Our global facilities are equipped to meet your drug substance needs, with dedicated development resources worldwide. As a reliable supply chain partner globally, we support your drug substance development goals.
We offer comprehensive support for custom API development, covering Route Scouting, Pre-GMP Kilo Lab, Process Development, and Analytical Development, with expertise and flexibility.
We offer manufacturing services at lab, kilo, and pilot scales, catering to preclinical studies, all stages of clinical trials, and commercialization, providing quantities ranging from milligrams to kilograms.
Piramal’s Generic API division provides a diverse range of off-patent APIs tailored for global markets.
Piramal’s Riverview facility offers High Potency API (HPAPI) services. Our teams are experts in the cGMP production of highly potent compounds, from grams to kilograms. With over 50 years of experience in manufacturing, handling, and containment of highly potent compounds, we prioritize safety and quality in all our operations.
